AlzForum Research News & Views

PIB-PET Biomarker Study Confirms Bapineuzumab Lowers Amyloid

5 Mar 2010 00:00:00 EST

Researchers have sunk many millions of dollars into the prospect that antibodies glomming onto Aβ peptides could help shrink amyloid plaques in the brains of AD patients...

Research Brief: Driven to Diffraction—X-rays Show APP Dimerization

5 Mar 2010 00:00:00 EST

There is more to amyloid precursor protein (APP) than the peptide for which it is named...

Dimebon Disappoints in Phase 3 Trial

4 Mar 2010 00:00:00 EST

One swallow does not make a summer, and one positive clinical trial does not make an Alzheimer�s drug...

Phoenix: Making Trials Work for Patient, Sponsor, Regulator

3 Mar 2010 00:00:00 EST

Exactly how to correctly fashion a pre-symptomatic trial appears to be in the eye of the beholder...

Paper Alert: Aβ�s Day Job—Slayer of Microbes?

3 Mar 2010 00:00:00 EST

Scientists assert the amyloidogenic peptide Aβ serves the physiological function of fighting off microbes as part of the body�s innate immune system...

DISC1: Brief Loss in Prenatal Life Leads to Problems Later On

2 Mar 2010 00:00:00 EST

If schizophrenia has its roots in early brain development, why does the disease most often appear in adolescence or early adulthood?...

Baby Steps for Gene Therapy? Fatal Infant Disease Cured in Mice

2 Mar 2010 00:00:00 EST

Is anyone, parent or physician, brave enough to allow gene therapy in newborn babies? The answer may come sooner than we think...

Phoenix: For Shared Prevention Trials, Devil Is in the Details

2 Mar 2010 00:00:00 EST

In Phoenix, senior industry and academic scientists, and regulatory and statistical advisers, dug deep into the details of a proposed pre-symptomatic trials initiative...

Phoenix: Trials in Colombia and the U.S. for Those at Highest Risk?

1 Mar 2010 00:00:00 EST

Researchers have laid out a vision for pre-symptomatic treatment trials that emphasize use of biomarkers to evaluate investigational drugs...

CaMKII: More Than Just an Enzyme; It�s a Scaffold, Too

27 Feb 2010 00:00:00 EST

To form and cement memories, the synapse must restructure itself, breaking down some proteins and rebuilding new configurations...