AlzForum Research News & Views

Honolulu: The Missing Link? Tau Mediates Aβ Toxicity at Synapse

26 Jul 2010 00:00:00 EST

For the first time, a paper details a molecular mechanism that links tau to Aβ toxicity at the synapse...

Honolulu: Wake-Up Call—Aβ Clearance, Not Production, Awry in AD

26 Jul 2010 00:00:00 EST

If β amyloid is indeed an early driver of Alzheimer disease pathogenesis, AD patients presumably churn out the peptide too quickly, clear it too slowly, or both...

Research Brief: SIRTs Keep Brain Minty Fresh

25 Jul 2010 00:00:00 EST

The sirtuin protein SIRT1 is emerging as an important player in learning and memory...

Honolulu: Tomm40 Reported to Track With Brain Atrophy, Cognition

23 Jul 2010 00:00:00 EST

Tomm40 has created a stir in AD research with the recent proposal that length of polymorphisms of this gene can help predict at what age a person may develop late-onset AD...

Honolulu: TrialMatch Launched as AD Is Becoming �Desktop� Disease

23 Jul 2010 00:00:00 EST

AD diagnosis is moving from the bedside to the desktop, suggests Jason Karlawish...

Research Brief: Combination Therapy Does the Trick for Old Dogs

23 Jul 2010 00:00:00 EST

Maybe you can teach old dogs new tricks—and reduce their amyloid-β burden...

The Protective Promise of Antioxidants, Vitamins

17 Jul 2010 00:00:00 EST

Two new papers show that vitamins may have potential as protectors for the brain...

Mechanisms and Memory: The Choreography of CREB, the Balance of BDNF

16 Jul 2010 00:00:00 EST

Two new papers detail specific, discrete pathways of memory formation that share a common element, namely, signaling by CREB...

Research Brief: Reelin Loss Ramps Up Aβ Pathology

16 Jul 2010 00:00:00 EST

The protein reelin helps rein in pathology in Alzheimer disease mice, according to a recent report...

Toxic TDP-43 Too Tough to Degrade, Plays Prion?

16 Jul 2010 00:00:00 EST

TDP-43 is intimately linked with ALS, but the mystery remains as to what the protein is normally meant to do, and what goes wrong when it mutates...